Among other things, including a large hunk of what was left of the class system after ME2 and ME3 gutted it. Personally, I liked said class system, but I apparently was overruled… well. Moving on, it looks like more sandbox and sex in this puppy; also, more opportunities for BS around with your companions. Oh, and a proper Mako for once.
All in all, it looks essentially fine – being Queen of the Girl Scouts isn’t a character class; it’s a life choice – but then, I’m the kind of guy who would make sure to beat Vega in a pull-up contest just to prove that I can, so I am clearly not without bias here.