He really goes out on a limb, here:
Domestically, there will be historic midterm contests that will reshape the entire political landscape, at least until the next election. I can see clearly that there will be far more losing than winning candidates, counting primary contenders. A fair number of the winners will eventually be found to be corrupt, having extramarital affairs, or involved in other categories of scandal. One more prediction is coming into focus: The November 2, 2010 results will be over-interpreted.
I wrote that while smiling, by the way. Larry Sabato was just having fun.