No Shepard, but we knew that already.
Not much is known about the next Mass Effect game other than that the fourth entry of the popular Bioware franchise will introduce a new protagonist since the Commander Shepard trilogy has ended. Production of the new title, however, has now become to become more involved after the developer began working on motion capture recording for the next game. According to a report by Gameranx on Jan 31, Bioware Cinematic Director Ken Thain revealed that the initial motion capture work for the next Mass Effect title started on Wednesday.
After all, we all saw her die*.
PS: Personally, I’d enjoy the hell out of playing out the war with the Turians. Although that might not be dramatic enough.
[OBLIGATORY SPOILER WARNING]