The question is apparently whether they can get away with a Deadpool that’s R-rated on his own, and PG-13 when he’s in the MCU. …Ah. Yes? Just tell Ryan Reynolds that he can crack wise about the restrictions onscreen at least once per MCU movie. And then everybody else will ignore it, because Deadpool is this crazy guy who thinks that he’s in a bunch of movies. This is part of the Deadpool brand, remember? They can lampshade any damned thing that they want, just by having it come out of the Mouth of the Merc.
Honestly, this isn’t really rocket science.