It’s an interesting question: apparently Tom Holland is under the impression that there’s going to be a trilogy of standalone Spider-Man movies. Certainly there’s going to be a sequel to Spider-Man: Homecoming, because that’s already been agreed to. And Spider-man will be in Avengers: Infinity War, because that’s already been agreed to, too. But Holland was specifically talking about a third Spider-Man standalone, which has not been agreed to. As we all know by now, Spidey’s in the MCU as the result of some extremely intricate negotiations between two media conglomerates who both had something to gain by working together (Disney got to put Spider-Man in a flick, Sony got the same with regard to Iron Man, and probably some other MCU earners). As that article notes, if they want to continue this, there’s got to be a new deal.
I suspect that there will be a new deal, actually. But that’s only if Spider-Man: Homecoming is a blockbuster. If it is, then sharing the toys is in everybody’s long-term business interests. Sony makes money off of Marvel intellectual properties in a way that doesn’t make them feel like they’re making the universe slightly worse, Disney gets access to Spider-Man merchandising revenue streams without having to be even a little bit illegal, oh, yeah, the fans get to see Spidey and Cap and Thor hang out, and everybody is happy.
If Spider-Man: Homecoming doesn’t tank. If it does, well, that’s why they call it an experiment. Just business, boychik.